Transcriptomics

Dataset Information

0

Interferon-Gamma- and Murine-CMV-Activated Primary Macrophages


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Nigel Binns  

PROVIDER: E-GEOD-42505 | ArrayExpress | 2015-07-10

SECONDARY ACCESSION(S): GSE42505PRJNA194070

REPOSITORIES: GEO, ArrayExpress

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Publications


Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN with the sterol network and the identity of sterol mediators remain unknown. Here we report a cellular antiviral role for macrophage production of 25-hydroxycholesterol (cholest-5-en-3β,25-diol, 25HC) as a component of the sterol metabolic network linked to the IFN response via Stat1. By utilizing quantitative metabolome profiling of all  ...[more]

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