Genomics

Dataset Information

4

Conversion of human fibroblast to endothelial cell by defined factors


ABSTRACT: Transient pluripotency-factor-based signaling-directed (TPS) transdifferentiation approach could be further applied to generate functional induced endothelial (iEnd) cells from human fibroblasts with only two factors: Oct4 and Klf4 (OK). The iEnd cells exhibit characteristic endothelial cell phenotype in vitro and in vivo and are capable of functionally promoting vascular regeneration and blood perfusion in a murine model of PAD. Human fibroblasts were transfected with Oct4 and Klf4 then changed to endothelial cell culture media with growth factors. iENDs were purified by FACS and enriched in EGM2 media.

ORGANISM(S): Homo sapiens  

SUBMITTER: Sheng Ding   Ngan Huang  Jun Li  jun li 

PROVIDER: E-GEOD-42672 | ArrayExpress | 2012-12-03

SECONDARY ACCESSION(S): GSE42672PRJNA182702

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-42672.idf.txt Idf
E-GEOD-42672.processed.1.zip Processed
E-GEOD-42672.raw.1.zip Raw
E-GEOD-42672.sdrf.txt Txt
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