Transcriptomics

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Myc and PI3-k induced gene expression in RWPE1


ABSTRACT: Analysis of transcriptional changes during Myc or PI3K induced oncogenic transformation in RWPE1 cells (benign prostate epithelial cell line). The aim of the present study was to identify key epigenetic gene silencing events that occur during the oncogenic transformation events, hence emphasis was placed on downregulated genes. Results provide important information on which are the tumor suppressive pathways or genes that will be epigenetically silenced by during Myc or PI3K induced oncogenic transformation. Total RNA obtained from oncogenic transformed RWPE1 cells which were either overexpressing Myc or constitutive active mutant of PI3K (E545K) as compared to RWPE1 cells expressing the empty vector control PMN.

ORGANISM(S): Homo sapiens  

SUBMITTER: Zhen Ning Wee  Qiang Yu   Zhenning Wee    

PROVIDER: E-GEOD-43686 | ArrayExpress | 2015-05-20

SECONDARY ACCESSION(S): GSE43686PRJNA187057

REPOSITORIES: GEO, ArrayExpress

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Publications

EZH2-mediated inactivation of IFN-γ-JAK-STAT1 signaling is an effective therapeutic target in MYC-driven prostate cancer.

Wee Zhen Ning ZN   Li Zhimei Z   Lee Puay Leng PL   Lee Shuet Theng ST   Lim Yoon Pin YP   Yu Qiang Q  

Cell reports 20140619 1


Although small-molecule targeting of EZH2 appears to be effective in lymphomas carrying EZH2 activating mutations, finding similar approaches to target EZH2-overexpressing epithelial tumors remains challenging. In MYC-driven, but not PI3K-driven prostate cancer, we show that interferon-γ receptor 1 (IFNGR1) is directly repressed by EZH2 in a MYC-dependent manner and is downregulated in a subset of metastatic prostate cancers. EZH2 knockdown restored the expression of IFNGR1 and, when combined wi  ...[more]

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