Transcriptomics

Dataset Information

13

Expression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection


ABSTRACT: CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here. The SMARTA TCR transgenic / adptive transfer system was used to identify and sort subsets of antigen-specific CD4 T cells (based on their expression of Ly6c and CXCR5) elicited after acute infection with LCMV (Arm).

ORGANISM(S): Mus musculus  

SUBMITTER: Scott Hale   Smita S Iyer  Ata R Mohammed  Lilin Ye  Tuoqi Wu  Ben A Youngblood  Donald R Latner  Rama S Akondy  Rafi Ahmed 

PROVIDER: E-GEOD-43863 | ArrayExpress | 2013-04-22

SECONDARY ACCESSION(S): GSE43863PRJNA187929

REPOSITORIES: GEO, ArrayExpress

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Publications

Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

Hale J Scott JS   Youngblood Ben B   Latner Donald R DR   Mohammed Ata Ur Rasheed AU   Ye Lilin L   Akondy Rama S RS   Wu Tuoqi T   Iyer Smita S SS   Ahmed Rafi R  

Immunity 20130411 4


CD4(+) T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody responses. However, it remains unclear whether there are CD4(+) memory T cells committed to the Tfh cell lineage after antigen clearance. By using adoptive transfer of antigen-specific memory CD4(+) T cell subpopulations in the lymphocytic choriomeningitis virus infection model, we found that there are distinct memory CD4(+) T cell populations wi  ...[more]

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