Transcriptomics

Dataset Information

3

Circulating miRNAs as novel marker of pulmonary hypertension


ABSTRACT: We determined pattern of miRNAs of mild-to-severe human pulmonary arterial hypertension and compared the with health controls using microarray and subsequently validated by QPCRs Manuscript Title: Circulating miRNAs as novel marker for pulmonary hypertension. (Under Revision Plos One Manuscript ID: PONE-D-12-38535) Performed microRNA microarray from one healthy and one severe PH patient and compared the results using additional samples by qPCR for other miRNAs

ORGANISM(S): Homo sapiens  

SUBMITTER: Sandeep Kumar   Chuanyu Wei  Christopher Spradley  Sudhiranjan Gupta  Il-Kwon Kim  Alejandro C Arroliga  Nayeon Hong  Heather Henderson 

PROVIDER: E-GEOD-44145 | ArrayExpress | 2013-11-01

SECONDARY ACCESSION(S): GSE44145PRJNA188774

REPOSITORIES: GEO, ArrayExpress

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Publications


MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary  ...[more]

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