Transcriptomics

Dataset Information

46

Transcription profiling of human skin samples from borderline tuberculoid leprosy and lepromatous leprosy patients


ABSTRACT: Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.

ORGANISM(S): Homo sapiens  

SUBMITTER: Joshua Bleharski   

PROVIDER: E-GEOD-443 | ArrayExpress | 2014-06-06

SECONDARY ACCESSION(S): GSE443GDS358PRJNA85029

REPOSITORIES: GEO, ArrayExpress

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Publications


Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mech  ...[more]

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