Transcriptomics

Dataset Information

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Gene expression in mouse leukocytes after CAWS administration


ABSTRACT: We performed DNA microarray analyses and compared the difference in the transcriptome between B6 and DBA/2 mice with modest or dramatic sensitivity to CAWS-vasculitis, respectively. Candida albicans water-soluble fraction (CAWS), a mannoprotein-β-glucan complex obtained from the culture supernatant of C. albicans NBRC1385, causes CAWS mediated vasculitis (CAWS-vasculitis) with distinct sensitivity among mouse strains. The mouse leukocyte derived from B6 and DBA/2 mice after 2-, 4-, 8-, 9- weeks administration were examined. Each mice was run in singlete or duplicate. Microarray analyses were performed as single-color hybridizations.

ORGANISM(S): Mus musculus  

SUBMITTER: Daisuke Okuzaki   Hiroshi Nojima 

PROVIDER: E-GEOD-44803 | ArrayExpress | 2013-09-30

SECONDARY ACCESSION(S): GSE44803PRJNA191819

REPOSITORIES: GEO, ArrayExpress

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Publications

CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice.

Nagi-Miura Noriko N   Okuzaki Daisuke D   Torigata Kosuke K   Sakurai Minami A MA   Ito Akihiko A   Ohno Naohito N   Nojima Hiroshi H  

BMC immunology 20130924


BACKGROUND: Candida albicans water-soluble fraction (CAWS), a mannoprotein-β-glucan complex obtained from the culture supernatant of C. albicans NBRC1385, causes CAWS-mediated vasculitis (CAWS-vasculitis) in B6 and DBA/2 mice with mild and lethal symptoms, respectively. Why CAWS is lethal only in DBA/2 mice remains unknown. RESULTS: We performed DNA microarray analyses using mRNA obtained from peripheral blood mononuclear cells (PBMCs) of B6 and DBA/2 mice and compared their respective transcrip  ...[more]

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