Transcriptomics,Multiomics

Dataset Information

4

Expression data from High-grade prostate cancer cells


ABSTRACT: To identify molecules to serve as diagnostic markers for high-grade prostate cancer (PC) and targets for novel therapeutic drugs, we investigated the gene expression profiles of high-grade PCs using a cDNA microarray combined with laser microbeam microdissection. For this study, we collected 10 frozen specimens from high-grade PCs with high PSA levels and high Gleason score (GS) in clinically using prostatic needle biopsy. All needle biopsy specimens were at clinical stages T2 to T4 with or without N1 and M1 and their GS were 8-9. Moreover, all 10 patients had not received androgen ablation therapy. Simultaneously, normal prostate (NP) epithelial cells were also microdissected from five non-prostate cancer (BPH) patients. These NP cells from five males were used as a normal mixture control for our cDNA microarray analysis.

OTHER RELATED OMICS DATASETS IN: PRJNA192832

ORGANISM(S): Homo sapiens  

TISSUE(S): Normal Prostate (np) Epithelial Cells, Prostate Cancer Cells

SUBMITTER: Taro Shuin   Hirofumi Satake  Kenji Tamura 

PROVIDER: E-GEOD-45016 | ArrayExpress | 2013-03-12

SECONDARY ACCESSION(S): GSE45016PRJNA192832

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-45016.idf.txt Idf
E-GEOD-45016.processed.1.zip Processed
E-GEOD-45016.raw.1.zip Raw
E-GEOD-45016.sdrf.txt Txt
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Publications

The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human prostate cancer.

Satake Hirofumi H   Tamura Kenji K   Furihata Mutsuo M   Anchi Takashi T   Sakoda Hatsune H   Kawada Chiaki C   Iiyama Tatsuo T   Ashida Shingo S   Shuin Taro T  

Oncology reports 20100101 1


To identify molecules to serve as diagnostic markers for high-grade prostate cancer (PC) and targets for novel therapeutic drugs, we investigated the gene expression profiles of high-grade PCs using a cDNA microarray combined with laser microbeam microdissection. We subsequently confirmed that the ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) was expressed exclusively in high-grade PCs with high Gleason scores. Semi-quantitative reverse transcription PCR and immunohistochemical a  ...[more]

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