Transcriptomics

Dataset Information

8

Constitutively Active Foxo3 in Oocytes Preserves Ovarian Reserve in Mice


ABSTRACT: During female reproductive life, the reserve of ovarian follicles is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. We asked if overexpression of a constitutively active FOXO3 protein can increase long-lasting ovarian reproductive capacity in mice. Trangenic vs non-transgenic mice onto Foxo3+/- vs Foxo3-/- genotype

ORGANISM(S): Mus musculus  

SUBMITTER: Chris Ottolenghi   Emanuele Pelosi 

PROVIDER: E-GEOD-45389 | ArrayExpress | 2013-06-08

SECONDARY ACCESSION(S): GSE45389PRJNA193681

REPOSITORIES: GEO, ArrayExpress

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Publications

Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice.

Pelosi Emanuele E   Omari Shakib S   Michel Marc M   Ding Jun J   Amano Tomokazu T   Forabosco Antonino A   Schlessinger David D   Ottolenghi Chris C  

Nature communications 20130101


During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the ovarian reserve in mice. Here we show that overexpression of constitutively active FOXO3 can increase ovarian reproductive capacity in mice. We find increased follicle numbers and decreased gonadotropin levels in aging FOXO3-transgenic mice compared with wild-type littermates, suggesting maintenance of a greater ovarian reserve. Based on cumulat  ...[more]

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