Transcriptomics

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Intestine-adapted bacterial symbiont response to polysaccharide rich and polysaccharide deficient diets in mice lacking fucosyltransferase-2


ABSTRACT: Analysis of Bacteroides thetaiotaomicron (BT) from the ceca of ex-germ free Fut2+ or Fut2- mice on polysaccharide rich or glucose rich polysaccharide deficient diet. BT is involved in the breakdown of plant polysaccharides and is also efficiently utilizes host glycans. BT-colonized mice represent a human gut ecosystem model. Results identify genes that may endow flexibility in adapting to dietary changes by mucosal foraging depending on host fucosylation status In vitro transcriptional profiles of Bacteroides thetaiotaomicron obtained from ceca of ex-germ free Fut2+ or Fut2- mice on polysaccharide rich or glucose rich polysaccharide deficient diet.

ORGANISM(S): Bacteroides thetaiotaomicron  

SUBMITTER: Justin L Sonnenburg   Purna Kashyap  Angela M Marcobal 

PROVIDER: E-GEOD-45641 | ArrayExpress | 2014-04-21

SECONDARY ACCESSION(S): GSE45641PRJNA195463

REPOSITORIES: GEO, ArrayExpress

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Publications

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota.

Kashyap Purna C PC   Marcobal Angela A   Ursell Luke K LK   Smits Samuel A SA   Sonnenburg Erica D ED   Costello Elizabeth K EK   Higginbottom Steven K SK   Domino Steven E SE   Holmes Susan P SP   Relman David A DA   Knight Rob R   Gordon Jeffrey I JI   Sonnenburg Justin L JL  

Proceedings of the National Academy of Sciences of the United States of America 20130923 42


We investigate how host mucus glycan composition interacts with dietary carbohydrate content to influence the composition and expressed functions of a human gut community. The humanized gnotobiotic mice mimic humans with a nonsecretor phenotype due to knockout of their α1-2 fucosyltransferase (Fut2) gene. The fecal microbiota of Fut2(-) mice that lack fucosylated host glycans show decreased alpha diversity relative to Fut2(+) mice and exhibit significant differences in community composition. A g  ...[more]

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