Transcriptomics

Dataset Information

308

Changes in PBMC gene expression profiles after influenza vaccination in healthy human subjects


ABSTRACT: Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. Temporal patterns of gene expression, determined by RNA-seq, in unfractionated PBMC suggested migration of myeloid/dendritic cell lineage cells one day after vaccination. Five subjects, 11 time points per subject (pre-vaccination and daily for 10 days post-vaccination)

ORGANISM(S): Homo sapiens  

SUBMITTER: Stephen L Welle   Stephen Welle  Alicia D Henn  Martin S Zand 

PROVIDER: E-GEOD-45735 | ArrayExpress | 2013-08-07

SECONDARY ACCESSION(S): SRP020492GSE45735PRJNA196146

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature.

Henn Alicia D AD   Wu Shuang S   Qiu Xing X   Ruda Melissa M   Stover Michael M   Yang Hongmei H   Liu Zhiping Z   Welle Stephen L SL   Holden-Wiltse Jeanne J   Wu Hulin H   Zand Martin S MS  

Scientific reports 20130101


To identify sources of inter-subject variation in vaccine responses, we performed high-frequency sampling of human peripheral blood cells post-vaccination, followed by a novel systems biology analysis. Functional principal component analysis was used to examine time varying B cell vaccine responses. In subjects vaccinated within the previous three years, 90% of transcriptome variation was explained by a single subject-specific mathematical pattern. Within individual vaccine response patterns, a  ...[more]

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