Transcriptomics,Genomics

Dataset Information

64

Atrial Identity Is Determined by A COUP-TFII Regulatory Network


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: San-pin Wu  

PROVIDER: E-GEOD-46498 | ArrayExpress | 2013-06-07

SECONDARY ACCESSION(S): GSE46498PRJNA200655

REPOSITORIES: GEO, ArrayExpress

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Publications


Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, the factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP-TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T tubules. Changes in atrial characteristics are accompanied by alterations of 2,584 genes, of  ...[more]

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