Transcriptomics

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Antitumoral activity of acadesine and rituximab in MCL


ABSTRACT: Acadesine is a nucleoside analogue with known antileukemic effects in different neoplasms. We investigated the activity of acadesine ne exerts a cytotoxic effect in MCL and synergizes with rituximab supporting clinical examination of this strategy for MCL patients We used microarrays to detail the gene expression changes in acadesine-, rituximab- and combination-treated tumors. Global RNA expression in tumors treated with acadesine, rituximab and the combination in a xenograft model of MCL (Jeko-1). Tumors were collected 18 days after the initiation of the treatments.

ORGANISM(S): Homo sapiens  

SUBMITTER: DOLORS COLOMER  Dolors Colomer   Arnau Montraveta    

PROVIDER: E-GEOD-47871 | ArrayExpress | 2013-06-13

SECONDARY ACCESSION(S): GSE47871PRJNA208230

REPOSITORIES: GEO, ArrayExpress

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