Transcriptomics

Dataset Information

2

Maternal obesity affects fetal neurodevelopmental and metabolic gene expression


ABSTRACT: To investigate fetal gene expression in obese compared to lean women in the second trimester, by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from obese cases and lean controls revealed differential expression of 205 genes. Functional analysis of differentially expressed genes suggested down-regulation of apoptosis in fetuses of obese women, particularly within nervous system pathways involving the cerebral cortex, and activation of pro-estrogenic, pro-inflammatory transcriptional regulators. Prospective whole transcriptome microarray study analyzing cell-free RNA in AF from obese cases and lean controls in the second trimester. Significantly differentially-regulated genes in fetuses of obese cases (N= 8) vs. matched lean controls (N = 8) were identified and functional analyses were performed. Tissue-specific differential gene expression in fetuses of obese women was also examined.

ORGANISM(S): Homo sapiens  

SUBMITTER: Heather C Wick   Andrea G Edlow  Diana W Bianchi  Lisa Hui  Neeta L Vora  Janet M Cowan 

PROVIDER: E-GEOD-48521 | ArrayExpress | 2013-07-04

SECONDARY ACCESSION(S): GSE48521PRJNA210420

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-48521.idf.txt Idf
E-GEOD-48521.processed.1.zip Processed
E-GEOD-48521.raw.1.zip Raw
E-GEOD-48521.sdrf.txt Txt
Items per page:
1 - 4 of 4

Similar Datasets

2014-01-01 | S-EPMC3928248 | BioStudies
2012-01-11 | E-GEOD-33168 | ArrayExpress
2013-05-28 | E-GEOD-47392 | ArrayExpress
2013-05-28 | E-GEOD-47393 | ArrayExpress
2009-05-21 | E-GEOD-16176 | ArrayExpress
2013-04-23 | E-GEOD-46286 | ArrayExpress
2010-12-03 | E-GEOD-25634 | ArrayExpress
2014-06-13 | E-GEOD-58435 | ArrayExpress
2015-12-17 | GSE60403 | GEO
2014-05-27 | E-GEOD-49891 | ArrayExpress