Dataset Information


Maternal obesity affects fetal neurodevelopmental and metabolic gene expression

ABSTRACT: To investigate fetal gene expression in obese compared to lean women in the second trimester, by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from obese cases and lean controls revealed differential expression of 205 genes. Functional analysis of differentially expressed genes suggested down-regulation of apoptosis in fetuses of obese women, particularly within nervous system pathways involving the cerebral cortex, and activation of pro-estrogenic, pro-inflammatory transcriptional regulators. Prospective whole transcriptome microarray study analyzing cell-free RNA in AF from obese cases and lean controls in the second trimester. Significantly differentially-regulated genes in fetuses of obese cases (N= 8) vs. matched lean controls (N = 8) were identified and functional analyses were performed. Tissue-specific differential gene expression in fetuses of obese women was also examined.

ORGANISM(S): Homo sapiens  

SUBMITTER: Heather C Wick   Andrea G Edlow  Diana W Bianchi  Lisa Hui  Neeta L Vora  Janet M Cowan 

PROVIDER: E-GEOD-48521 | ArrayExpress | 2013-07-04



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E-GEOD-48521.idf.txt Idf Processed Raw
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