Transcriptomics

Dataset Information

40

The effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model


ABSTRACT: In this study, we investigated the effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model as vitamin D is known to have a spectrum of anticancer activities. Using PET, we found that tumor formation and progression were suppressed in rats fed a diet supplemented with 6 IU/g vitamin D3(+6D) as compared to the group fed a 2 IU/g vitamin D3 diet (+2D) or controls. Microarray analysis of the tumors that arose revealed that vitamin D supplementation caused significant up- and down regulation in 21 and 16 genes, respectively. There are 9 tissue samples (3 rats in each group labeled as (+6), (+2) and control). Duplicate analysis were used for each sample.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Ta-Sen Yeh  Tzu-Chen Yen   Kun-Chun Chiang   Miin-Fu Chen   Kun-Ju Lin   Tai C Chen   Chi-Chin Sun   Li-Jen Su   Chun-Nan Yeh   Horng-Heng Juang   Jong-Hwei S Pang   Yi-Yin Jan   Atsushi Kittaka    

PROVIDER: E-GEOD-48961 | ArrayExpress | 2015-08-19

SECONDARY ACCESSION(S): GSE48961PRJNA212404

REPOSITORIES: GEO, ArrayExpress

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