Transcriptomics

Dataset Information

3

The effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model


ABSTRACT: In this study, we investigated the effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model as vitamin D is known to have a spectrum of anticancer activities. Using PET, we found that tumor formation and progression were suppressed in rats fed a diet supplemented with 6 IU/g vitamin D3(+6D) as compared to the group fed a 2 IU/g vitamin D3 diet (+2D) or controls. Microarray analysis of the tumors that arose revealed that vitamin D supplementation caused significant up- and down regulation in 21 and 16 genes, respectively. There are 9 tissue samples (3 rats in each group labeled as (+6), (+2) and control). Duplicate analysis were used for each sample.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Ta-Sen Yeh   Tzu-Chen Yen  Kun-Chun Chiang  Miin-Fu Chen  Kun-Ju Lin  Tai C Chen  Chi-Chin Sun  Li-Jen Su  Chun-Nan Yeh  Horng-Heng Juang  Jong-Hwei S Pang  Yi-Yin Jan  Atsushi Kittaka 

PROVIDER: E-GEOD-48961 | ArrayExpress | 2015-08-01

SECONDARY ACCESSION(S): GSE48961PRJNA212404

REPOSITORIES: GEO, ArrayExpress

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