Transcriptomics

Dataset Information

119

Regulatory consequences of ZNF395 knock-down in MDA-LM2-shTARBP2 cell-line


ABSTRACT: shRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of ZNF395 resulted in a significant up-regulation in several key oncogenes. ZNF395 was knocked-down, via expression of short-hairpin RNAs targeting its transcript. The cells were then subjected to transcripome profiling in comparison to mock-transfected cells.

OTHER RELATED OMICS DATASETS IN: E-GEOD-49608

ORGANISM(S): Homo sapiens  

SUBMITTER: H Goodarzi   Hani Goodarzi  L Fish  C G Buss  S Zhang  S F Tavazoie  S Tavazoie 

PROVIDER: E-GEOD-49613 | ArrayExpress | 2014-07-24

SECONDARY ACCESSION(S): GSE49613PRJNA214601

REPOSITORIES: GEO, ArrayExpress

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Publications

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi Hani H   Zhang Steven S   Buss Colin G CG   Fish Lisa L   Tavazoie Saeed S   Tavazoie Sohail F SF  

Nature 20140709 7517


Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modula  ...[more]

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