Genomics

Dataset Information

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Glucocorticoid Receptor and Androgen Receptor DNA binding in LREX'


ABSTRACT: LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Emily Schenkein   Deyou Zheng  Bic MSKCC  Charles L Sawyers  Vivek K Arora 

PROVIDER: E-GEOD-51497 | ArrayExpress | 2013-12-27

SECONDARY ACCESSION(S): GSE51497SRP031653PRJNA223314

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR substituted for the androgen receptor (AR) to activate a similar but distinguishable set of target genes and was necessary for maintenance of the resistant phenotype. The GR agonist  ...[more]

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