Transcriptomics

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Transcriptomic profiling of HeLa cells infected with Salmonella Typhimurium


ABSTRACT: We evaluated the transcriptome changes induced by infection with Salmonella (20 hpi, MOI 100). Transcriptmic profiles of HeLa cells infected with Salmonella Typhimurium were generated by deep sequencing, using Illumina HiSeq 2000.

REANALYSED by: E-GEOD-53280

ORGANISM(S): Homo sapiens  

SUBMITTER: Mauro Giacca   Claire Maudet  Malvika Sharan  Miguel Mano  Ana Eulalio  Konrad U Förstner  Ushasree Sunkavalli  Konrad U. Förstner 

PROVIDER: E-GEOD-53280 | ArrayExpress | 2014-07-18

SECONDARY ACCESSION(S): GSE53280SRP034009PRJNA231559

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection.

Maudet Claire C   Mano Miguel M   Sunkavalli Ushasree U   Sharan Malvika M   Giacca Mauro M   Förstner Konrad U KU   Eulalio Ana A  

Nature communications 20140822


Increasing evidence suggests an important role for miRNAs in the molecular interplay between bacterial pathogens and host cells. Here we perform a fluorescence microscopy-based screen using a library of miRNA mimics and demonstrate that miRNAs modulate Salmonella infection. Several members of the miR-15 miRNA family were among the 17 miRNAs that more efficiently inhibit Salmonella infection. We discovered that these miRNAs are downregulated during Salmonella infection, through the inhibition of  ...[more]

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