Transcriptomics

Dataset Information

3

MicroRNA expression data from human high-density lipoproteins.


ABSTRACT: We quantified differential microRNA (miRNA) expression on human HDL before and after incubation with human coronary artery endothelial cells. These data were used to determine which miRNAs are altered on HDL (taken up or effluxed to) by human coronary artery endothelial cells. Each group had a n=4 and HDL-miRNA levels post incubations were compared to pre incubations with cells.

OTHER RELATED OMICS DATASETS IN: E-GEOD-53201

ORGANISM(S): Homo sapiens  

SUBMITTER: Kasey C Vickers   Fatiha Tabet 

PROVIDER: E-GEOD-53314 | ArrayExpress | 2014-02-27

SECONDARY ACCESSION(S): GSE53314PRJNA231676

REPOSITORIES: GEO, ArrayExpress

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Publications


High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppresses expression of intercellular adhesion molecule 1 (ICAM-1) through the transfer of miR-223 to endothelial cells. After incubation of endothelial cells with HDL, mature miR-223 levels are significantly increased in endothelial cells and decreased o  ...[more]

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