Transcriptomics

Dataset Information

88

Transcriptomic analyses of Kras induced zebrafish liver cancer


ABSTRACT: The kras transgenic line was generated by using a mifepristone-inducible transgenic system in combination with a Cre-loxP system. Most of the induced transgenic fish developed hepatocellular carcinoma at 6 month-post-induction. Transcriptome profiling of Kras tumor sample (6T1 and 6T2) and control samples (6M1 and 6M2) were generated by deep sequencing, using 3' RNA-SAGE on SOLiD system

ORGANISM(S): Danio rerio  

SUBMITTER: Alexander Emelyanov  Zhiyuan Gong   Weiling Zheng   Anh T Nguyen    

PROVIDER: E-GEOD-53630 | ArrayExpress| 2014-04-15

SECONDARY ACCESSION(S): SRP034710GSE53630PRJNA232516

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications

Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma.

Zheng Weiling W   Li Zhen Z   Nguyen Anh Tuan AT   Li Caixia C   Emelyanov Alexander A   Gong Zhiyuan Z  

PloS one 20140314 3


Previously three oncogene transgenic zebrafish lines with inducible expression of xmrk, kras or Myc in the liver have been generated and these transgenic lines develop oncogene-addicted liver tumors upon chemical induction. In the current study, comparative transcriptomic approaches were used to examine the correlation of the three induced transgenic liver cancers with human liver cancers. RNA profiles from the three zebrafish tumors indicated relatively small overlaps of significantly deregulat  ...[more]

Similar Datasets

2013-05-09 | E-GEOD-40745 | ArrayExpress
2013-09-26 | E-GEOD-48427 | ArrayExpress
2015-09-06 | E-GEOD-66036 | ArrayExpress
2016-07-11 | E-GEOD-70150 | ArrayExpress
2016-08-06 | E-GEOD-82223 | ArrayExpress
2016-07-10 | E-GEOD-79525 | ArrayExpress
2016-08-14 | E-GEOD-83638 | ArrayExpress
2012-11-06 | E-GEOD-34914 | ArrayExpress
2013-11-25 | E-GEOD-43314 | ArrayExpress
2015-12-27 | E-GEOD-75600 | ArrayExpress