Transcriptomics

Dataset Information

4

BRAF siRNA NHGRI_Liang_BRAF


ABSTRACT: BRAF, one of three RAF serine/threonine kinases (ARAF, BRAF and CRAF), plays a major role in the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway, which mediates cellular responses to growth signals. Recently a high frequency (~60%-70%) of activating BRAF mutations (predominantly V600E) has been reported in malignant melanoma. In order to identify the downstream effects of BRAF signaling on melanoma cell growth and gene expression, cDNA microarray analysis was carried out following BRAF siRNA or MEK1/2 inhibitor (U0126) treatment. Keywords: time series, siRNA time series, siRNA, drug treatment

ORGANISM(S): Homo sapiens  

SUBMITTER: Sean Davis   Yizheng Liang  Paul S Meltzer 

PROVIDER: E-GEOD-5481 | ArrayExpress | 2013-07-07

SECONDARY ACCESSION(S): GSE5481PRJNA95999

REPOSITORIES: GEO, ArrayExpress

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