Dataset Information


Whole genome profiling of whole liver lysates of vehicle and Sorafenib-treated iAST mice

ABSTRACT: Analysis of changes in gene expression upon Sorafenib treatment. Looking for candidates, that could potentially be up- or down-regulated upon Sorefanib treatment. Total RNA were optained from whole liver lysates of vehicle 14d-, Sorafenib 14d- and LT Sorafenib-treated iAST mice

ORGANISM(S): Mus musculus  

SUBMITTER: Hellmut Augustin   Anja Runge 

PROVIDER: E-GEOD-54857 | ArrayExpress | 2014-06-20



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An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice.

Runge Anja A   Hu Junhao J   Wieland Matthias M   Bergeest Jan-Philip JP   Mogler Carolin C   Neumann André A   Géraud Cyrill C   Arnold Bernd B   Rohr Karl K   Komljenovic Dorde D   Schirmacher Peter P   Goerdt Sergij S   Augustin Hellmut G HG  

Cancer research 20140606 15

The limited availability of experimental tumor models that faithfully mimic the progression of human tumors and their response to therapy remains a major bottleneck to the clinical translation and application of novel therapeutic principles. To address this challenge in hepatocellular carcinoma (HCC), one of the deadliest and most common cancers in the world, we developed and validated an inducible model of hepatocarcinogenesis in adult mice. Tumorigenesis was triggered by intravenous adenoviral  ...[more]

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