Transcriptomics

Dataset Information

3

Evaluating mRNA and microRNA profiles reveals discriminative and compound-specific responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Linda Rieswijk  

PROVIDER: E-GEOD-57132 | ArrayExpress | 2015-05-18

SECONDARY ACCESSION(S): GSE57132PRJNA245530

REPOSITORIES: GEO, ArrayExpress

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Publications

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Rieswijk Linda L   Brauers Karen J J KJ   Coonen Maarten L J ML   van Breda Simone G J SG   Jennen Danyel G J DG   Kleinjans Jos C S JC  

Mutagenesis 20150514 6


Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However, the complex mechanisms by which NGTX carcinogens act are less clear and may result in conflicting results between species [e.g. Wy-14,643 (Wy)]. We hypothesise that common microRNA response pathways exist for each class of carcinogenic agents. Therefore, this study compares and integrates mRNA and microRNA expression profiles following shor  ...[more]

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