Transcriptomics

Dataset Information

6

Identification of genes differentially expressed in lung cancer cells after the transfection of miR-221 or miR-222.


ABSTRACT: To evaluate involvement of miR-221 and miR-222 in lung cancer, we investigated the effects of miR-221 and miR-222 overexpression on six lung cancer cell lines as well as one immortalized normal human bronchial epithelial cell line. Two cell lines, H3255 and H1299 with no replicates were studied. Cells were transfected with miR-221, miR-222, or miR control. Microarray analysis was done to identify genes differentially expressed in lung cancer cells after the transfection of miR-221 or miR-222.

ORGANISM(S): Homo sapiens  

SUBMITTER: Satoshi Kondo   Mitsuo Sato  Ryo Yamashita 

PROVIDER: E-GEOD-57676 | ArrayExpress | 2015-05-22

SECONDARY ACCESSION(S): GSE57676PRJNA247686

REPOSITORIES: GEO, ArrayExpress

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Publications

Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells.

Yamashita Ryo R   Sato Mitsuo M   Kakumu Tomohiko T   Hase Tetsunari T   Yogo Naoyuki N   Maruyama Eiichi E   Sekido Yoshitaka Y   Kondo Masashi M   Hasegawa Yoshinori Y  

Cancer medicine 20150130 4


Both pro- and anti-oncogenic roles of miR-221 and miR-222 microRNAs are reported in several types of human cancers. A previous study suggested their oncogenic role in invasiveness in lung cancer, albeit only one cell line (H460) was used. To further evaluate involvement of miR-221 and miR-222 in lung cancer, we investigated the effects of miR-221 and miR-222 overexpression on six lung cancer cell lines, including H460, as well as one immortalized normal human bronchial epithelial cell line, HBEC  ...[more]

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