Transcriptomics

Dataset Information

4

Expression profiling tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition


ABSTRACT: Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-inhibitor MLN8237 (n=3) for 24 h. The expression profiles of vehicle (DMSO)-treated mNB-A1 cells were compared to JQ1- or MLN8237-treated mNB-A1 cells.

ORGANISM(S): Mus musculus  

SUBMITTER: Alexander Schramm   Johannes Schulte  Kristina Althoff 

PROVIDER: E-GEOD-57810 | ArrayExpress | 2014-09-01

SECONDARY ACCESSION(S): GSE57810PRJNA248139

REPOSITORIES: GEO, ArrayExpress

Similar Datasets

| GSE82032 | GEO
2014-03-01 | E-GEOD-49124 | ArrayExpress
2016-03-31 | E-GEOD-75960 | ArrayExpress
2015-06-25 | E-GEOD-70263 | ArrayExpress
2015-05-01 | E-GEOD-57203 | ArrayExpress
2016-02-12 | E-GEOD-70577 | ArrayExpress
| GSE87477 | GEO
| GSE81915 | GEO
| GSE76188 | GEO
2015-12-31 | E-GEOD-68690 | ArrayExpress