Transcriptomics

Dataset Information

35

Expression profiling tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition


ABSTRACT: Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-inhibitor MLN8237 (n=3) for 24 h. The expression profiles of vehicle (DMSO)-treated mNB-A1 cells were compared to JQ1- or MLN8237-treated mNB-A1 cells.

ORGANISM(S): Mus musculus  

SUBMITTER: Alexander Schramm  Johannes Schulte   Kristina Althoff    

PROVIDER: E-GEOD-57810 | ArrayExpress | 2014-09-06

SECONDARY ACCESSION(S): GSE57810PRJNA248139

REPOSITORIES: GEO, ArrayExpress

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