Transcriptomics

Dataset Information

37

Expression data from 128 Desmoids


ABSTRACT: One of the main problems in managing desmoids tumors is their locoregional aggressiveness and their high ability to recur after initial treatment. In our work, with the goal to identify molecular markers that can predict Progression-Free Survival, gene-expression screening was conducted on 128 available independent untreated primary desmoid tumors using cDNA microarray. By analyzing expression profiles, we have identified, for the first time, a gene expression signature that is able to predict Progression-Free Survival. This molecular signature identified two groups with clearly distinct Progression-Free Survival in the two sets of subjects. Patients in good prognostic group had achieved a progression-free 2-year survival rate of 86% while patients in poor prognostic group had a progression-free 2-year survival rate of 44%. 128 available independent untreated primary desmoid tumors

ORGANISM(S): Homo sapiens  

SUBMITTER: Céline Brulard  céline brulard   Frédéric Chibon   Sébastien Salas    

PROVIDER: E-GEOD-58697 | ArrayExpress| 2015-05-22

SECONDARY ACCESSION(S): GSE58697PRJNA253192

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival.

Salas Sébastien S   Brulard Celine C   Terrier Philippe P   Ranchere-Vince Dominique D   Neuville Agnes A   Guillou Louis L   Lae Marick M   Leroux Agnes A   Verola Olivier O   Jean-Emmanuel Kurtz K   Bonvalot Sylvie S   Blay Jean-Yves JY   Le Cesne Axel A   Aurias Alain A   Coindre Jean-Michel JM   Chibon Frederic F  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150415 18


Because desmoid tumors exhibit an unpredictable clinical course, translational research is crucial to identify the predictive factors of progression in addition to the clinical parameters. The main issue is to detect patients who are at a higher risk of progression. The aim of this work was to identify molecular markers that can predict progression-free survival (PFS).Gene-expression screening was conducted on 115 available independent untreated primary desmoid tumors using cDNA microarray. We e  ...[more]

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