Transcriptomics

Dataset Information

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BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein


ABSTRACT: Coordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Persistence of oncogenic p27 functions despite effective inhibition of BCR-ABL1 may contribute to resistance to tyrosine kinase inhibitors. BCR-ABL1 induced p27 versus knockout, controlling with Empty vector p27 versus knock out

ORGANISM(S): Mus musculus  

SUBMITTER: Michael Deininger   Anupriya Agarwal  Sophia Jeng 

PROVIDER: E-GEOD-59168 | ArrayExpress | 2014-10-08

SECONDARY ACCESSION(S): SRP044124GSE59168PRJNA254523

REPOSITORIES: GEO, ArrayExpress, ENA

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