Transcriptomics

Dataset Information

24

DNA Methylation Analysis of Systemic Lupus Erythematosus


ABSTRACT: This study performed Illumina Methylation450 analysis of CD4+ T-cells, CD19+ B-cells and CD14+ Monocytes from lupus patients and controls. A validation cohort was further analyzed with the same platform using CD4+ T-cells, CD45RO-CD45RA+ naive T-cells, CD45RO+CD45RA- memory T-cells, and CD25+CD127- regulatory T-cells. SLE v Control comparisions were made within each cell type. The SLE patient samples are labeled SLEnnnn and the controls Xnnnn. The cell type CD4, CD14, CD19, Tmem, Treg, Tnaive is appended to each sample ID.

ORGANISM(S): Homo sapiens  

SUBMITTER: Devin Absher  

PROVIDER: E-GEOD-59250 | ArrayExpress | 2014-07-10

SECONDARY ACCESSION(S): GSE59250PRJNA254821

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations.

Absher Devin M DM   Li Xinrui X   Waite Lindsay L LL   Gibson Andrew A   Roberts Kevin K   Edberg Jeffrey J   Chatham W Winn WW   Kimberly Robert P RP  

PLoS genetics 20130808 8


Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic, epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we collected CD4+ T-cells, CD19+ B-cells, and CD14+ monocytes from 49 SLE patients and 58 controls, and performed genome-wide DNA methylation analysis with Illumina Methylation 450 microarrays. We identified 166 CpGs in B-cells, 97 CpGs in monocytes, and 1,033 CpGs in T-cells with highly significant changes in DNA methylation le  ...[more]

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