Transcriptomics

Dataset Information

4

LNCaP cells: shRNA library with bicalutamide


ABSTRACT: Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth Vehicle vs. bicalutamide treated LNCaP cells infected with lentiviral shRNA library. Biological replicates: 2 vehicle treatments, 2 bicalutamide treatments.

ORGANISM(S): Homo sapiens  

SUBMITTER: Satoshi Inoue   Kazuhiro Ikeda 

PROVIDER: E-GEOD-60382 | ArrayExpress | 2015-05-15

SECONDARY ACCESSION(S): GSE60382PRJNA258197

REPOSITORIES: GEO, ArrayExpress

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Publications

Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway.

Maruyama Yojiro Y   Miyazaki Toshiaki T   Ikeda Kazuhiro K   Okumura Toshiyuki T   Sato Wataru W   Horie-Inoue Kuniko K   Okamoto Koji K   Takeda Satoru S   Inoue Satoshi S  

PloS one 20141006 10


Androgen receptor is a primary transcription factor involved in the proliferation of prostate cancer cells. Thus, hormone therapy using antiandrogens, such as bicalutamide, is a first-line treatment for the disease. Although hormone therapy initially reduces the tumor burden, many patients eventually relapse, developing tumors with acquired endocrine resistance. Elucidation of the molecular mechanisms underlying endocrine resistance is therefore a fundamental issue for the understanding and deve  ...[more]

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