Transcriptomics

Dataset Information

592

Thymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.


ABSTRACT: Gene expression analysis of purified KitL-tomato+ and KitL-tomato- thymic vascular endothelial cells, cortical and medullary thymic epithelial cells from 5 weeks old male kitL-tomato reporter mice Differentially expressed genes analysis of thymic stromal cells

REANALYSED by: E-GEOD-62741

ORGANISM(S): Mus musculus  

SUBMITTER: S E Jacobsen   A Giustacchini  Claus Nerlov  S Thongjuea  M Buono  Supat Thongjuea 

PROVIDER: E-GEOD-62741 | ArrayExpress | 2016-01-18

SECONDARY ACCESSION(S): SRP049302GSE62741PRJNA265043

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

Buono Mario M   Facchini Raffaella R   Matsuoka Sahoko S   Thongjuea Supat S   Waithe Dominique D   Luis Tiago C TC   Giustacchini Alice A   Besmer Peter P   Mead Adam J AJ   Jacobsen Sten Eirik W SE   Nerlov Claus C  

Nature cell biology 20160118 2


Thymic T cell development is initiated from bone-marrow-derived multi potent thymus-seeding progenitors. During the early stages of thymocyte differentiation, progenitors become T cell restricted. However, the cellular environments supporting these critical initial stages of T cell development within the thymic cortex are not known. Here we use the dependence of early, c-Kit-expressing thymic progenitors on Kit ligand (KitL) to show that CD4(-)CD8(-)c-Kit(+)CD25(-) DN1-stage progenitors associat  ...[more]

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