Transcriptomics

Dataset Information

88

Transcriptome-wide modulation of splicing by the exon junction complex


ABSTRACT: We report that knockdown of EJC core proteins, eIF4A3, Y14, Magoh, causes a transcript-wide changes in alternative splicing, as well as some transcriptional changes. These changes are specific to EJC core proteins, and KD of UPF1 protein caused different sets of alterantive splicing changes. These changes are linked to the rate of transcription. Examination of 4 different knockdown, as well as GFP knockdown in HeLa cells, 2 replicates each condition.

ORGANISM(S): Homo sapiens  

SUBMITTER: Zhen Wang  Valentine Murigneux   Herve Le Hir   Herve LE HIR    

PROVIDER: E-GEOD-63091 | ArrayExpress| 2014-11-28

SECONDARY ACCESSION(S): SRP049611GSE63091PRJNA266584

REPOSITORIES: GEO, ArrayExpress, ENA

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