Transcriptomics

Dataset Information

296

Transcriptome-wide modulation of splicing by the exon junction complex


ABSTRACT: We report that knockdown of EJC core proteins, eIF4A3, Y14, Magoh, causes a transcript-wide changes in alternative splicing, as well as some transcriptional changes. These changes are specific to EJC core proteins, and KD of UPF1 protein caused different sets of alterantive splicing changes. These changes are linked to the rate of transcription. Examination of 4 different knockdown, as well as GFP knockdown in HeLa cells, 2 replicates each condition.

ORGANISM(S): Homo sapiens  

SUBMITTER: Zhen Wang   Valentine Murigneux  Herve Le Hir  Herve LE HIR 

PROVIDER: E-GEOD-63091 | ArrayExpress | 2014-11-14

SECONDARY ACCESSION(S): SRP049611GSE63091PRJNA266584

REPOSITORIES: GEO, ArrayExpress, ENA

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