Transcriptomics

Dataset Information

6

MicroRNA expression profile in macrophages from rheumatoid arthritis and osteoarthritis patients


ABSTRACT: In osteoarthritis (OA) and rheumatoid arthritis (RA), many pathological alterations result from aberrant macrophage hyperactivation in the inflamed synovial membrane, and inhibition of macrophage effector functions is a therapeutic strategy in both diseases. Little is known, about the specific genetic circuits that are differentially deregulated in RA and OA macrophages. microRNA (miR) are short single stranded non-coding RNAs involved in the post-transcriptional regulation of gene expression. Altered expression of miRs has been described under various pathological conditions, including rheumatic and other autoimmune diseases. Here we compared the miR expression profile in macrophages isolated from OA and RA patients miR expression in OA and RA macrophages was analyzed using Exiqon miRCURY microarrays. Three biological replicates (patients) were analyzed. Two samples (RA vs OA) were hybridized per microarray.

ORGANISM(S): Homo sapiens  

SUBMITTER: Manuel Tardáguila   Juan D Cañete  Juan Carlos Oliveros  Jesús Ogando  Andrea Díaz-Alderete  Vanessa Miranda-Ramos  Alicia Isategui  José L Pablos  Santos Mañes 

PROVIDER: E-GEOD-63745 | ArrayExpress | 2016-02-05

SECONDARY ACCESSION(S): GSE63745PRJNA268962

REPOSITORIES: GEO, ArrayExpress

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Publications


Evidence links aryl hydrocarbon receptor (AHR) activation to rheumatoid arthritis (RA) pathogenesis, although results are inconsistent. AHR agonists inhibit pro-inflammatory cytokine expression in macrophages, pivotal cells in RA aetiopathogenesis, which hints at specific circuits that regulate the AHR pathway in RA macrophages. We compared microRNA (miR) expression in CD14(+) cells from patients with active RA or with osteoarthritis (OA). Seven miR were downregulated and one (miR-223) upregulat  ...[more]

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