Transcriptomics

Dataset Information

3

A Genome-wide Gene Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology


ABSTRACT: The purpose of this project was to compare whole genome expression in 5 transgenic mice with human genes for dementia that result in either plaques or tangle pathology to the expression in wild-type control mice and to each other at different stages of disease progression. Total RNA was obtained from hippocampus, cortex and cerebellum in four lines of ‘amyloid’ transgenic mice (mutant human APP and APP/PSEN1 genes) and ‘TAU’ transgenic mice (mutant human MAPT gene) as well as wild-type control mice at 8,16, 32 and 72 weeks

ORGANISM(S): Mus musculus  

SUBMITTER: T G Moens   J Latcham  D S Salih  K J Smith  Frances Edwards  R Desai  M S Guelfi  J C Richardson  S Ali  M Yasvoina  Paublete R Moreno  M Perona  M Matarin  J Hardy  M A Nahaboo  F A Edwards  D M Cummings  W Liu  M Fulleylove 

PROVIDER: E-GEOD-64398 | ArrayExpress | 2014-12-24

SECONDARY ACCESSION(S): GSE64398PRJNA270888

REPOSITORIES: GEO, ArrayExpress

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