Transcriptomics

Dataset Information

30

Expression comparison of mutant EGFR-driven gliomas with relapse tumors upon mutant EGFR ablation


ABSTRACT: To determine the roles of oncogenic EGFR signaling in gliomagenesis and tumor maintenance, we generated a novel glioma mouse model driven by inducible expression of a mutant EGFR (EGFR*). Genetic suppression of EGFR* induction led to significant tumor regression and prolonged survival. But in spite of the initial response, the tumors relapsed invariably and propagated independent of EGFR*. We used microarrys to directly compare geen expression of control and relapse tumors and identified gene sets specifically activated in relapse tumors. Control and relasped glioma samples upon mutant EGFR extinction were selected for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus  

SUBMITTER: Ling Zhang  Y Wang   Peter Canoll   Haoqiang Ying   Angelina V Vaseva   Stefan Klingler   Hongwu Zheng   James W Horner   Sida Chen   Jun Yao   Baofeng Guo   Haiyan Yan   Ji-hye Paik    

PROVIDER: E-GEOD-64751 | ArrayExpress| 2015-01-10

SECONDARY ACCESSION(S): GSE64751PRJNA271792

REPOSITORIES: GEO, ArrayExpress

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