Transcriptomics

Dataset Information

297

Transcriptome analyses of skeletal muscle in αB-crystallin/HspB2 knockout and wild-type mice on a normal or high fat diet


ABSTRACT: We profiled the skeletal muscle transcriptome between wild type and αB-crystallin/HspB2 knock mice exposed to normal chow and high fat diets to examine the role of αB-crystallin/HspB2 in diet induced obesity. Combined with metabolic profiling of the mice, these data reveal that αB-crystallin/HspB2 is involved in the genesis of insulin resistance on a high fat diet, and we provide extensive RNA profiling to illuminate potential mechanistic insights into the muscle-specific role of αB-crystallin/HspB2. Hind limb muscle mRNA profiles of wild type and αB-crystallin/HspB2 knock mice exposed to either normal chow or high fat diets using RNAseq analysis

ORGANISM(S): Mus musculus  

SUBMITTER: Daniel Toft   Daniel J Toft  Brian T Layden 

PROVIDER: E-GEOD-66557 | ArrayExpress | 2015-09-01

SECONDARY ACCESSION(S): GSE66557SRP055864PRJNA277320

REPOSITORIES: GEO, ArrayExpress, ENA

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