Transcriptomics

Dataset Information

2

Renal Cell Carcinomas in Vinylidene Chloride Exposed Male B63FC1 Mice Are Characterized by Oxidative Stress and TP53 Overexpression


ABSTRACT: Vinylidene Chloride has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increase in renal cell hyperplasias, adenomas, and carcinomas (RCCs). Global gene expression analysis showed overrepresentation of pathways associated with chronic xenobiotic and oxidative stress in RCCs from VDC-exposed B6C3F1 mice, as well as cMyc overexpression and dysregulation of Tp53 cell cycle checkpoint and DNA damage repair pathways. Trend analysis comparing RCC, VDC-exposed kidney, and vehicle control kidney showed a conservation of pathway dysregulation in terms of overrepresentation of xenobiotic and oxidative stress, and DNA damage and cell cycle checkpoint pathways in both VDC-exposed kidney and RCC, suggesting that these mechanisms play a role in the development of RCC in VDC-exposed mice. Compare mouse renal cell carcinoma versus treated kidney and vehicle control normal kidney, 6 replicates each group.

ORGANISM(S): Mus musculus  

SUBMITTER: Mark J Hoenerhoff   Arun R Pandiri  NIEHS Microarray Core 

PROVIDER: E-GEOD-67320 | ArrayExpress | 2015-12-21

SECONDARY ACCESSION(S): GSE67320PRJNA279500

REPOSITORIES: GEO, ArrayExpress

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Publications

Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Hayes Schantel A SA   Pandiri Arun R AR   Ton Thai-vu T TV   Hong Hue-Hua L HH   Clayton Natasha P NP   Shockley Keith R KR   Peddada Shyamal D SD   Gerrish Kevin K   Wyde Michael M   Sills Robert C RC   Hoenerhoff Mark J MJ  

Toxicologic pathology 20151217 1


Vinylidene chloride (VDC) has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 mice to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increases in renal cell hyperplasia, renal cell adenoma, and renal cell carcinomas (RCCs). Among those differentially expressed genes from controls and RCC of VDC-exposed mice, there was an overrepresentation of genes from pathways associated with chronic xenobiotic and oxi  ...[more]

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