Dataset Information


Transcription profiling of human and mouse breast cancers

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE6581: Expression data from mammary glands of transgenic mice; GSE6596: Comparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes Experiment Overall Design: Refer to individual Series

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Musculus  

SUBMITTER: Andreas Klein  

PROVIDER: E-GEOD-6772 | ArrayExpress | 2008-06-15



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Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set.

Klein Andreas A   Wessel Ralf R   Graessmann Monika M   Jürgens Martin M   Petersen Iver I   Schmutzler Rita R   Niederacher Dieter D   Arnold Norbert N   Meindl Alfons A   Scherneck Siegfried S   Seitz Susanne S   Graessmann Adolf A  

International journal of cancer 20070801 3

The aim of our work was to establish a database for breast cancer gene expression data in order to compare human and mouse breast cancer. We identified human and mouse homologues genes and compared the expression profile of 24 human breast tumors with 6 WAP-SVT/t breast tumors (WAP-SVT/t animals, line 8). Our studies confirmed the heterogeneity in gene expression of human as well as mouse breast cancer cells. However, 63 genes were found to be differentially expressed (upregulated: 40; downregul  ...[more]

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