Transcriptomics,Genomics

Dataset Information

243

1,25(OH)2D3 time course in THP-1 cells


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Carsten Carlberg  

PROVIDER: E-GEOD-69303 | ArrayExpress | 2016-07-03

SECONDARY ACCESSION(S): GSE69303PRJNA285106

REPOSITORIES: GEO, ArrayExpress

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Publications

Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF.

Seuter Sabine S   Neme Antonio A   Carlberg Carsten C  

Nucleic acids research 20151228 9


The physiological functions of vitamin D are mediated by its metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) activating the transcription factor vitamin D receptor (VDR). In THP-1 human monocytes we demonstrated epigenome-wide effects of 1,25(OH)2D3 at 8979 loci with significantly modulated chromatin accessibility. Maximal chromatin opening was observed after 24 h, while after 48 h most sites closed again. The chromatin-organizing protein CTCF bound to 14% of the 1,25(OH)2D3-sensitive chromat  ...[more]

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