Dataset Information


Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury

ABSTRACT: We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates its detrimental effect, we analyzed the transcriptome of the injured spinal cord of Il1a-KO, Il1b-KO and C57BL/6 mice at 24 hours after SCI using GeneChip microarrays. Il1a-KO, Il1b-KO and C57BL/6 mice were subjected to a 50-kdyn SCI and a 6-mm spinal cord segment centered over the site of contusion extracted for RNA isolation and microarray analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Steve Lacroix  

PROVIDER: E-GEOD-70302 | ArrayExpress | 2015-06-27



Similar Datasets

2015-12-07 | E-GEOD-42828 | ArrayExpress
2016-06-08 | PXD003375 | Pride
2013-08-22 | E-GEOD-45376 | ArrayExpress
2013-11-12 | E-GEOD-51685 | ArrayExpress
1000-01-01 | S-EPMC6021489 | BioStudies
2020-04-24 | PXD015060 | Pride
2010-10-19 | E-GEOD-20460 | ArrayExpress
2020-01-01 | S-EPMC7096134 | BioStudies
2012-01-01 | S-EPMC3278405 | BioStudies
2017-01-01 | S-EPMC5394902 | BioStudies