Dataset Information


Genome-wide analysis of Estrogen Receptor-mediated response to acute Estradiol treatment in liver

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Raphaël Métivier  

PROVIDER: E-GEOD-70350 | ArrayExpress | 2016-05-13



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Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 Treatment.

Palierne Gaëlle G   Fabre Aurélie A   Solinhac Romain R   Le Péron Christine C   Avner Stéphane S   Lenfant Françoise F   Fontaine Coralie C   Salbert Gilles G   Flouriot Gilles G   Arnal Jean-François JF   Métivier Raphaël R  

Molecular Endocrinology 20160510 7

Transcriptional regulation by the estrogen receptor-α (ER) has been investigated mainly in breast cancer cell lines, but estrogens such as 17β-estradiol (E2) exert numerous extrareproductive effects, particularly in the liver, where E2 exhibits both protective metabolic and deleterious thrombotic actions. To analyze the direct and early transcriptional effects of estrogens in the liver, we determined the E2-sensitive transcriptome and ER cistrome in mice after acute administration of E2 or place  ...[more]

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