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Dataset Information

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Omics score: 14

Transcription profiling of human peripheral blood leukocytes from CHASRS particpants

ABSTRACT: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Experiment Overall Design: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation.

OTHER RELATED OMICS DATASETS IN: PRJNA98191

INSTRUMENT(S): 418 [Affymetrix]

SUBMITTER: Steve Cole

PROVIDER: E-GEOD-7148 | ArrayExpress | 2009-04-23

SECONDARY ACCESSION(S): GDS3207GSE7148PRJNA98191

REPOSITORIES: GEO, ArrayExpress

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			Action	DRS
	E-GEOD-7148.README.txt	Txt
	E-GEOD-7148.eSet.r	Other
	E-GEOD-7148.idf.txt	Idf
	E-GEOD-7148.processed.1.zip	Processed
	E-GEOD-7148.raw.1.zip	Raw

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Publications

Social regulation of gene expression in human leukocytes.

Cole Steve W SW Hawkley Louise C LC Arevalo Jesusa M JM Sung Caroline Y CY Rose Robert M RM Cacioppo John T JT

Genome biology 20070101 9

<h4>Background</h4>Social environmental influences on human health are well established in the epidemiology literature, but their functional genomic mechanisms are unclear. The present study analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates.<h4>Resu ...[more]

PMID: 17854483

Similar Datasets

Differential gene expression in peripheral blood leukocytes from CHASRS particpants

Project description:Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation. Keywords: Risk prediction Overall design: Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of social isolation.

2007-11-02 | GSE7148 | GEO

The role of perceived social support on depression and sleep during the COVID-19 pandemic.

Project description:The aim of the present study was to examine the role of perceived social support pertaining to a range of psychological health outcomes amongst individuals undergoing social isolation and social distancing during COVID-19. A total of 2,020 participants provided responses to an online cross-sectional survey comprised of validated instruments including the Multidimensional Scale of Perceived Social Support (MSPSS), the Generalized Anxiety Disorder Scale (GAD-7), the Patient Health Questionnaire (PHQ-9), the Brief Irritability Test (BITe) and the UCLA Loneliness Scale (UCLA-LS). Individuals experiencing self-isolation had significantly higher rates of depression, irritability and loneliness compared to those who were not. The risk for elevated levels of depression symptoms was 63% lower in individuals who reported higher levels of social support compared to those with low perceived social support. Similarly, those with high social support had a 52% lower risk of poor sleep quality compared to those with low social support. Social support was found to be significantly associated with elevated risk for depression and poorer sleep quality. The results contribute to our understanding of differential psychological outcomes for individuals experiencing anti-pandemic measures.

2020-01-01 | S-EPMC7500407 | BioStudies

Social isolation and loneliness as risk factors for the progression of frailty: the English Longitudinal Study of Ageing.

Project description:Background:loneliness and social isolation have been associated with mortality and with functional decline in older people. We investigated whether loneliness or social isolation are associated with progression of frailty. Methods:participants were 2,817 people aged ?60 from the English Longitudinal Study of Ageing. Loneliness was assessed at Wave 2 using the Revised UCLA scale (short version). A social isolation score at Wave 2 was derived from data on living alone, frequency of contact with friends, family and children, and participation in social organisations. Frailty was assessed by the Fried phenotype of physical frailty at Waves 2 and 4, and by a frailty index at Waves 2-5. Results:high levels of loneliness were associated with an increased risk of becoming physically frail or pre-frail around 4 years later: relative risk ratios (95% CI), adjusted for age, sex, level of frailty and other potential confounding factors at baseline were 1.74 (1.29, 2.34) for pre-frailty, and 1.85 (1.14, 2.99) for frailty. High levels of loneliness were not associated with change in the frailty index-a broadly based measure of general condition-over a mean period of 6 years. In the sample as a whole, there was no association between social isolation and risk of becoming physically frail or pre-frail, but high social isolation was associated with increased risk of becoming physically frail in men. Social isolation was not associated with change in the frailty index. Conclusion:older people who experience high levels of loneliness are at increased risk of becoming physically frail.

| S-EPMC5920346 | BioStudies

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 5

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Overall design: Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 98 adults in Year 5 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

| GSE65213 | GEO

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 9

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 92 adults in Year 9 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

2015-11-23 | E-GEOD-65341 | BioStudies

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 7

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 62 adults in Year 7 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

2015-11-23 | E-GEOD-65298 | BioStudies

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 10

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 100 adults in Year 10 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

2015-11-23 | E-GEOD-65403 | ArrayExpress

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 9

2015-11-23 | E-GEOD-65341 | ArrayExpress

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 5

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 98 adults in Year 5 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

2015-11-23 | E-GEOD-65213 | ArrayExpress

Leukocyte gene expression as a function of perceived social isolation (PSI): Year 8

Project description:Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 93 adults in Year 8 of the Chicago Health Aging and Social Relations Study. Participants were assessed for PSI using the UCLA Loneliness Scale, and were also classified as chronically high in PSI (1/0) based on UCLA Loneliness Scale scores during study years 1-5. A 1-year lagged value of PSI is also included, and analyses additionally controlled for age at study entry, sex, race/ethnicity (dummy codes for Black and Hispanic), marital status, (log) household income, Body Mass Index (BMI), smoking history, heavy alcohol consumption, depressive symptoms (CESD), perceived stress (PSS), social support (SocSupp), circulating monocyte percentages, and RNA indicators of major leukocyte subsets (CD3E, CD3D, CD4, CD8A, CD19, FCGR3A/CD16, NCAM1/CD56, CD14).

2015-11-23 | E-GEOD-65317 | ArrayExpress