Transcriptomics

Dataset Information

4

Mouse lung tissue transcriptome response to influenza H5N1 and mutants.


ABSTRACT: The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse lung infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203') and VN1203-NS1trunc124. Groups of 22-week-old C57BL/6 mice were infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203') and VN1203-NS1trunc124 (an NS1 protein with a 90 amino acid truncation at the C-terminus). Infections were done at 10^4 PFU/mouse in 50 μl PBS. Time points were 1, 2, 4, and 7 d.p.i. There were 5 mice for all infection groups and 3 mice for all mock groups. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.

ORGANISM(S): Mus musculus  

SUBMITTER: Amie J Eisfeld   Kelly Stratton  Katrina M Waters  Yoshihiro Kawaoka 

PROVIDER: E-GEOD-71759 | ArrayExpress | 2015-08-06

SECONDARY ACCESSION(S): GSE71759PRJNA292023

REPOSITORIES: GEO, ArrayExpress

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