Dataset Information


Identification of a Highly Immunogenic Mouse Breast Cancer Sub Cell Line, 4T1-S

ABSTRACT: Recently, cancer immunotherapy has been paid much attention because of its improved efficacy and low frequency of adverse effects. A mouse breast cancer cell line, 4T1, has been known as poorly immunogeneic and highly metastatic cell line. In this study, we have identified a sub cell line of 4T1, designated as 4T1-Sapporo (4T1-S), which could induce a strong immune response against the same line. When 4T1-S was subcutaneously injected, striking enlargement of draining lymph nodes and increase of activated T cells were observed. The strong immune responses could not be observed when 4T1-S was injected to nude mice, indicating that this phenomenon is mediated by T cell response. Identification of 4T1-S characteristics may help to improve immunotherapy against breast cancer. 4T1-A1, 4T1-A2, 4T1-S1, 4T1-S2

ORGANISM(S): Mus musculus  

SUBMITTER: Ken-ichiro Seino   Hirotake Abe  Hirotake ABE 

PROVIDER: E-GEOD-71926 | ArrayExpress | 2015-11-01



Similar Datasets

2014-04-01 | E-GEOD-53444 | ArrayExpress
2014-08-31 | E-GEOD-52690 | ArrayExpress
2010-07-07 | GSE19221 | GEO
2010-07-07 | E-GEOD-19221 | ArrayExpress
2015-03-31 | E-GEOD-67408 | ArrayExpress
2016-03-01 | E-GEOD-75122 | ArrayExpress
| GSE63180 | GEO
2013-05-11 | E-GEOD-28465 | ArrayExpress
2016-06-15 | E-GEOD-83319 | ArrayExpress
2011-07-24 | E-GEOD-30885 | ArrayExpress