Dataset Information


Transcription profiling of mouse

ABSTRACT: Affymetrix genechip profiling analsysis (MOE430A and MOE430B) of murine neuroblastoma cells infected with either RML prion strain or mock brain homogenate Experiment Overall Design: Parental N2a cells were split into 6 aliquots, 3 of which were infected with RML prions and 3 of which were mock-infected with normal brain homogenate. There are three biological replicates in total for each experimental group.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: Gino Miele  

PROVIDER: E-GEOD-7229 | ArrayExpress | 2008-04-07



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Transcriptional stability of cultured cells upon prion infection.

Julius Christian C   Hutter Gregor G   Wagner Ulrich U   Seeger Harald H   Kana Veronika V   Kranich Jan J   Klöhn Peter-Christian PC   Weissmann Charles C   Miele Gino G   Aguzzi Adriano A  

Journal of molecular biology 20071112 5

Prion infections induce severe disruption of the central nervous system with neuronal vacuolation and extensive glial reactions, and invariably lead to death of affected individuals. The molecular underpinnings of these events are not well understood. To better define the molecular consequences of prion infections, we analyzed the transcriptional response to persistent prion infection in a panel of three murine neural cell lines in vitro. Colony spot immunochemistry assays indicated that 65-100%  ...[more]

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