Transcriptomics

Dataset Information

356

RNA-seq for monitoring expression changes in absence of chromatin anchoring


ABSTRACT: RNA-seq for monitoring expression levels in mutants that do not anchor chromatin at the nuclear periphery. RNA-seq of depleted rRNA samples of early embryo extracts for three different genotypes: wild-type, cec-4_delta and met-2 set-25_delta_delta, in two independent biological replicas

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Dimos Gaidatzis   Adriana Gonzalez-Sandoval 

PROVIDER: E-GEOD-74067 | ArrayExpress | 2015-12-11

SECONDARY ACCESSION(S): SRP064859GSE74067PRJNA298898

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis elegans embryos, H3K9 methylation is necessary to silence and to anchor repeat-rich heterochromatin at the nuclear periphery. In a screen for perinuclear anchors of heterochromatin, we identified a previously uncharacterized C. elegans chromodomain protein, CEC-4. CEC-4 binds preferentially mono-, di-, or tri-methylated H3K9 and localizes at th  ...[more]

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