Transcriptomics

Dataset Information

62

Expression data from adult mouse Nucleus Accumbens following prenatal infection


ABSTRACT: Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the nucleus accumbens of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection. We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the nucleus accumbens.

ORGANISM(S): Mus musculus  

SUBMITTER: Urs Meyer   Marco A Riva  Annamaria Cattaneo  Juliet Richetto 

PROVIDER: E-GEOD-77971 | ArrayExpress | 2016-03-01

SECONDARY ACCESSION(S): GSE77971PRJNA312224

REPOSITORIES: GEO, ArrayExpress

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