Transcriptomics

Dataset Information

0

RNAseq from disomic and trisomic fibroblasts and lymphoblastoids


ABSTRACT: RNA was sequenced from individuals Disomic and Trisomic for chromosome 21 to identify consistent changes in gene expression across individuals Cells were cultured at subconfluency and RNA harvested for sequencing

ORGANISM(S): Homo sapiens  

SUBMITTER: Ahwan Pandey   Kelly D Sullivan  Leisa P Jackson  Joaquín M Espinosa 

PROVIDER: E-GEOD-79842 | ArrayExpress | 2016-07-29

SECONDARY ACCESSION(S): GSE79842SRP072769PRJNA317170

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells s  ...[more]

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