Transcriptomics

Dataset Information

5

DH06 Adrenal ACTH Sus scrofa


ABSTRACT: Large White and Meishan pigs were either non-treated or injected with mammalian 1-24 ACTH (Immediate Synachten, Novartis France) at the dose of 250 µg per animal. Pigs were sacrificed either immediately after capture from their home cage (non-treated animals) or 1 hour following ACTH injection. Adrenal glands were immediately collected from pigs and frozen on dry ice and then stored at -80°C until RNA isolation. Keywords: stress response, adrenal, gene expression, pig 47 samples

ORGANISM(S): Sus scrofa  

SUBMITTER: Dominique Hazard 

PROVIDER: E-GEOD-8377 | ArrayExpress | 2010-06-29

SECONDARY ACCESSION(S): GSE8377PRJNA101413

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene array and real time PCR analysis of the adrenal sensitivity to adrenocorticotropic hormone in pig.

Hazard Dominique D   Liaubet Laurence L   Sancristobal Magali M   Mormède Pierre P  

BMC Genomics 20080227


BACKGROUND: Variability in hypothalamic-pituitary-adrenal (HPA) axis activity has been shown to be influenced by genetic factors and related to great metabolic differences such as obesity. The aim of this study was to investigate molecular bases of genetic variability of the adrenal sensitivity to ACTH, a major source of variability, in Meishan (MS) and Large White (LW) pigs, MS being reported to exhibit higher basal cortisol levels, response to ACTH and fatness than LW. A pig cDNA microarray wa  ...[more]

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