Transcriptomics

Dataset Information

10

Transcription profiling of human patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status


ABSTRACT: This study supports an active role for PLZF and RARα-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct; epigenetic effects contributing to the leukemic phenotype. Experiment Overall Design: 5 patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status. This is a rare disease.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Ken Mills  

PROVIDER: E-GEOD-8510 | ArrayExpress | 2008-06-16

SECONDARY ACCESSION(S): GSE8510PRJNA101625

REPOSITORIES: GEO, ArrayExpress

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Publications

RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.

Guidez Fabien F   Parks Sarah S   Wong Henna H   Jovanovic Jelena V JV   Mays Ashley A   Gilkes Amanda F AF   Mills Kenneth I KI   Guillemin Marie-Claude MC   Hobbs Robin M RM   Pandolfi Pier Paolo PP   de Thé Hugues H   Solomon Ellen E   Grimwade David D  

Proceedings of the National Academy of Sciences of the United States of America 20071113 47


Leukemia-associated chimeric oncoproteins often act as transcriptional repressors, targeting promoters of master genes involved in hematopoiesis. We show that CRABPI (encoding cellular retinoic acid binding protein I) is a target of PLZF, which is fused to RARalpha by the t(11;17)(q23;q21) translocation associated with retinoic acid (RA)-resistant acute promyelocytic leukemia (APL). PLZF represses the CRABPI locus through propagation of chromatin condensation from a remote intronic binding eleme  ...[more]

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