Transcriptomics

Dataset Information

43

Comparative genomic hybridization to study capsule switching between serogroup C and W of Neisseria meningitidis strains


ABSTRACT: Changing antigenic structure such as capsule polysaccharide is a common strategy for bacterial pathogen to evade host immune system. In this regard, the recent emergence of an invasive W:2a:P1.7-2,4 ST-11 strain in New Zealand, which is an uncommon pathogenic serogroup, was investigated for its genetic origins. Molecular typing of 103 meningococcal isolates with similar serotyping characteristics was undertaken to determine genetic relationships. Results indicated that the W:2a:P1.7-2,4 strain had emerged via capsule switching from an existing group C strain (C:2a:P1.7 2,4). Neither of the upstream and downstream sites of recombination could be elucidate but sequence analysis demonstrated that at least 45 kb of DNA was involved in the recombination event. This included the entire capsule gene cluster. Genomic DNA isolated from serogroup C strains (n=4) and serogroup W strains (n=4) were compared using Pan-neisseria DNA microarray.

ORGANISM(S): Neisseria meningitidis  

SUBMITTER: Ming-Shi Li  

PROVIDER: E-MEXP-1910 | ArrayExpress | 2009-06-03

REPOSITORIES: ArrayExpress

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Publications

Evidence for capsule switching between carried and disease-causing Neisseria meningitidis strains.

Beddek Amanda J AJ   Li Ming-Shi MS   Kroll J Simon JS   Jordan T William TW   Martin Diana R DR  

Infection and immunity 20090518 7


Changing antigenic structure such as with capsule polysaccharide is a common strategy for bacterial pathogens to evade a host immune system. The recent emergence of an invasive W:2a:P1.7-2,4 sequence type 11 (ST-11) strain of Neisseria meningitidis in New Zealand, an uncommon serogroup/serotype in New Zealand disease cases, was investigated for its genetic origins. Molecular typing of 107 meningococcal isolates with similar serotyping characteristics was undertaken to determine genetic relations  ...[more]

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